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Bioengineering Seminar Series: Ian White
Friday, September 6, 2013
9:00 a.m.-10:00 a.m.
Pepco Room, Jeong H. Kim Engineering Building
For More Information:
Yu Chen
yuchen@umd.edu
Inkjet-Printed Fluidic Paper SERS Devices for Chemical and Biological Analytics
Ian White
Assistant Professor
Fischell Department of Bioengineering
University of Maryland
As a bio/chemical sensing technique, surface enhanced Raman spectroscopy (SERS) offers sensitivity comparable to that of fluorescence detection while providing highly specific information about the analyte. The high sensitivity of SERS detection results from the localized plasmons generated at the surface of noble metal nanostructures upon excitation by resonant electric fields at optical frequencies. Although single molecule identification with SERS was demonstrated over a decade ago, today a need exists to develop practical solutions for point-of-sample and point-of-care SERS systems. Recently, we demonstrated the fabrication of SERS substrates by inkjet printing silver and gold nanostructures onto paper. Using a low-cost commercial inkjet printer, we printed silver nanoparticles with micro-scale precision to form SERS-active biosensors. Using these devices, we have been able to achieve detection limits comparable to conventional nanofabricated substrates. Furthermore, we leverage the fluidic properties of paper to enhance the performance of the SERS devices while also enabling unprecedented ease of use. Paper dipsticks concentrate a relatively large sample volume into a small SERS-active detection region at the tip. Likewise, paper swabs collect samples from a large surface area and concentrate the collected molecules into a SERS sensor on the paper. In addition, the inherent chromatographic properties of paper enable sample cleanup and analyte separation to improve detection in complex real-world samples.
In this seminar, the capabilities of SERS as a chemical and biological sensing technique will be reviewed. Our research group’s progress in the fabrication and use of paper-based fluidic devices for SERS-based detection will then be presented, and the use of the paper devices in practical applications for point-of-sample chemical and biological analysis will be described. In particular, results will be presented from recent accomplishments in using the paper SERS devices as multiplexed detection elements following TaqMan PCR for infectious disease diagnostic applications.
 About the Speaker
Ian White is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland. Dr. White received his Ph.D. in Electrical Engineering from Stanford University in 2002, where he developed next generation optical metropolitan area communication networks. He then served as a Member of Technical Staff at Sprint’s Advanced Technology Laboratories until 2005. At that time, Dr. White transitioned into the field of optical biosensors as a Postdoctoral Fellow in the University of Missouri Life Sciences Center. In 2008, Dr. White joined the faculty in the Fischell Department of Bioengineering at the University of Maryland. His research group aims to develop novel microsystems for applications in chemical analytics and disease diagnosis.
This Event is For: Graduate • Faculty • Post-Docs
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